Table 2.
The effect of donor age and cytomegalovirus (CMV) serostatus on CD8+ T cells subsets within peripheral blood.
| Age (years) | Group | n = (M/F) | CD8+ lymphocytes ± s.d. | CD8+ LFA-1low (naïve) CD8 T cells ± s.d. | CD8+ LFA-1hi (memory) CD8 T cells ± s.d. | CD45RA+ LFA-1hi (revertant memory) CD8 T cells ± s.d. |
|---|---|---|---|---|---|---|
| 20–40 | CMV+ | 8 (4/4) | 788 ± 162 | 205 ± 43 | 584 ± 142 | 164 ± 43 |
| CMV− | 18 (9/9) | 711 ± 63 | 344 ± 44 | 367 ± 33 | 79 ± 16 | |
| 40–60 | CMV+ | 12 (6/6) | 553 ± 84 | 106 ± 13 | 448 ± 82 | 160 ± 37 |
| CMV− | 10 (7/3) | 417 ± 38 | 173 ± 15 | 243 ± 29 | 54 ± 7·7 | |
| 60+ | CMV+ | 47 (12/35) | 614 ± 78 | 70 ± 7·3 | 544 ± 76 | 181 ± 25 |
| CMV− | 29 (10/19) | 437 ± 40 | 106 ± 14 | 332 ± 33 | 73 ± 9·5 |
The effect of age on the CD8 T cell count is significant (P = 0·038). Age and CMV have a significant effect on naive CD8 T cell numbers (P = 1·32E-17 and 4·01E-05 respectively). CMV also has a significant effect on memory CD8 T cells and CD45RA+ memory CD8 T cells (P = 0·0025 and P = 7·37E-08) respectively. LFA, lymphocyte function-associated antigen; M/F, male/female; s.d., standard deviation.