Table 5.
The effect of age and cytomegalovirus (CMV) on B cells µl/blood.
| Age | Group | n = M/F | B cells | CD5+ B cells µl/blood | CD27− B cells | CD27+ B cells |
|---|---|---|---|---|---|---|
| 20–40 | CMV+ | 6 (2/4) | 151·4 (±51·7) | 0·911 (±0·567) | 145·2 (±51·4) | 6·2 (±2·03) |
| CMV− | 14 (8/6) | 247 (±123·0) | 3·07 (±7·64) | 225·3 (±100·9) | 21·7 (±25·4) | |
| 40–60 | CMV+ | 9 (4/5) | 154·4 (±70·1) | 3·1 (±7·70) | 143·5 (±62·6) | 11 (±7·6) |
| CMV− | 8 (6/2) | 149·6 (±87·4) | 1·09 (±0·888) | 138·3 (±77·6) | 11·3 (±9·9) | |
| 60+ | CMV+ | 39 (10/29) | 171·8 (±95·5) | 1·93 (±2·25) | 155·6 (±78·1) | 16·2 (±20·0) |
| CMV− | 29 (10/19) | 148·4 (±79·5) | 8·34 (±21·2) | 137·0 (±68·6) | 11·4 (±11·5) |
CMV has a significant effect on absolute the absolute B cell count (P = 0·0082). Significant interaction was found with respect to age, CMV and gender and the absolute and CD5+ B cell numbers. Age had a significant effect on the CD5+ B cell count in CMV-seropositive males only, P = 0·00235 (CD5+ B cells increase with advancing age). Age, gender and CMV did not have a significant effect on memory (CD27+ B cells). Age had a significant effect on naive (CD27− B cells) which decrease in number with advancing age. M/F, male/female.