Table 2.
Radionucleotide incorporation in sarcoidosis lymph nodes.
| [3H]-labelled multi-nucleated giant cells | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [3H]-thymidine | [3H]-uridine | [3H]-uridine | |||||||||||||
| Lymph node | d MGC | n | − | ± | + | n | − | ± | (%) | + | MGC | Sections | − | + | (per) |
| 58 | 0·45 | 7 | 7 | 0 | 0 | 12 | 6 | 5 | (42) | 1 | LH6 | 6 | 40 | 64 | 61 |
| LH7 | 7 | 64 | 26 | 24 | |||||||||||
| 60 | 0·37 | 12 | 12 | 0 | 0 | 11 | 7 | 3 | (27) | 1 | LH1 | 6 | 3 | 75 | 96 |
| LH2 | 7 | 17 | 43 | 72 | |||||||||||
| LH6 | 7 | 17 | 35 | 65 | |||||||||||
| FB4 | 4 | 25 | 18 | 42 | |||||||||||
| FB5 | 5 | 58 | 10 | 15 | |||||||||||
| 56 | 0·35 | 17 | 17 | 0 | 0 | 26 | 7 | 8 | (31) | 11 | nt | – | – | – | – |
| 57 | 0·31 | nt | 10 | 4 | 4 | (40) | 2 | nt | – | – | – | – | |||
| 66 | 0·23 | 25 | 25 | 0 | 0 | 14 | 3 | 4 | (29) | 7 | FB1 | 9 | 48 | 191 | 80 |
| LH1 | 5 | 81 | 31 | 28 | |||||||||||
| 53 | 0·11 | 7 | 7 | 0 | 0 | 3 | 1 | 1 | – | 1 | nt | – | – | – | – |
| 59 | 0·07 | 3+ | 3+ | 0+ | 0+ | 2+ | 1+ | 1+ | – | 0+ | nt | – | – | – | – |
| Number of MGC | 71 | 71 | 0 | 0 | 78 | 29 | 26 | (33) | 23 | nt | – | – | – | – | |
Radio nucleotide incorporation in sarcoidosis lymph nodes. Lymph node, sarcoidosis lymph node obtained from patient no. X; d MGC, density of giant cells per granulomas: (number of LH-MGC as well as FB-MGC)/30 granulomas; n, total number of observed multi-mucleated giant cells (MGC) per lymph node; −, number of MGC without any RNA or DNA synthesizing nuclei; ±, number of MGC with radio-labelled as well as unlabelled nuclei in the same giant cell; +, number of MGC in which all nuclei are labelled; (%), percentage of MGC which contains [3H]-uridine-labelled as well as unlabelled nuclei; nt, not tested; LH7, seventh evaluated Langhans MGC as observed in seven successive sections from lymph node 58; FB4, fourth foreign body MGC as observed in four successive sections from node 60; sections, number of serial sections of the same MGC; (per), percentage of radiolabelled nuclei in one MGC.