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. 2009 Mar;155(3):577–586. doi: 10.1111/j.1365-2249.2008.03837.x

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© 2009 British Society for Immunology

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Fig. 1 — (a) Genetic map of chromosomes 3 and 4 in non-obese diabetic (NOD).1101 and NOD.c3c4 mice. The NOD.1101 strain is free from spontaneous autoimmune biliary disease and includes a portion of the B6-derived chromosome 3 region present in NOD.c3c4 mice but not the B10-derived chromosome 4 segment (labelled Abd1). (b) The structures of lipoic acid and 2-octynoic acid (2OA)-bovine serum albumin (BSA). 2OA was conjugated with BSA and used for immunization. ‘Z’ represents the lysine residue of BSA.