. Author manuscript; available in PMC: 2009 Apr 16.

Published in final edited form as: Nat Struct Mol Biol. 2008 Jul 27;15(8):849–857. doi: 10.1038/nsmb.1457

Table 1.

Activity of Serrate mutants expressed in the Drosophila 3rd instar wing imaginal disc

Serrate mutant^*	18°C		29°C
	INH	TA	INH	TA
WT	+++	+++	lethal
Triple R251A+R253A+D255A	0	0	0	0
Double F249A+F257A	0	0	nd	nd
F249A (F199)	0	0	++	(+)
R253A (R203)	0	0	++	0
D255A (D205)	+	++	nd	nd
F257A (F207)	0	0	0	0
E265A (N215)	+++	+++	lethal
R251A (R201)	++	++	nd	nd

The number in parentheses refers to the equivalent residue in the human Jagged-1 protein sequence. INH- defined as the ability to inhibit endogenous D/V boundary formation, TA-trans-activation of Notch signalling.