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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Heart Rhythm. 2008 Sep 6;5(12):1726–1734. doi: 10.1016/j.hrthm.2008.09.008

Figure 2.

Figure 2

Representative records of concentration-dependent biphasic proarrhythmic and antiarrhythmic effects of quinidine in the presence of 1 nmol/L ATX-II in a female rabbit heart paced at 1 Hz. Monophasic action potentials (top record in each panel) and ECG (bottom record in each panel) were simultaneously recorded. Drug effects recorded during constant pacing at 1 Hz (A–E) and after a 3-second pause (F–J) are shown. Arrowsindicate spontaneous or 3-second pause-triggered episodes of torsade de pointes.