Table 1.
Electron micrograph morphometry of the liver endothelium and perisinusoidal hepatocytes from rat livers with and without pyocyanin treatment in vivo
| No treatment (n = 5) | Pyocyanin treatment (n = 7) | P-value | |
|---|---|---|---|
| Scanning electron microscopy | |||
| Porosity % | 3.4 ± 0.2 | 1.3 ± 0.1 | <0.001 |
| No. of fenestrations (μm2) | 5.5 ± 0.3 | 2.4 ± 0.1 | <0.001 |
| Fenestration diameter (nm) | 80.4 ± 0.6 | 71.0 ± 0.8 | <0.001 |
| Transmission electron microscopy | |||
| Endothelial thickness (nm) | 175.8 ± 5.8 | 156.5 ± 4.0 | <0.01 |
With pyocyanin treatment, scanning electron micrograph analysis revealed a decrease in porosity, fenestration diameter and fenestration frequency of liver sinusoids. With pyocyanin treatment, transmission electron micrograph analysis revealed a decrease in endothelial thickness. Data are presented as numerical values ± standard error of the mean.