Figure 6.

α-SMA immunohistohemistry (magnification 10×). (a) α-SMA expression was located around the blood vessels (portal venules and hepatic arteries; black arrows) in control and sham-operated mice. No staining of hepatic stellate cells was observed (b, c). In contrast, after induction of CCl₄ or CBDL, there was a progressive accumulation of α-SMA positive spindle-shaped cells along the sinusoidal wall within the fibrous septa in the pericentral or periportal area respectively (red arrows; hepatic artery: black arrow).