Figure 7.
Intravital fluorescence microscopy (objective magnification 10× and 20×). (a) A normal hepatic microcirculation was observed in control and sham-operated mice (20×). Sinusoids (black arrow), portal venules and central venules (white arrows) had a normal structure. In contrast, a marked distortion was seen after 16 weeks of CCl4 administration (b) (10×) and 6 weeks of common bile duct ligation (c) (10×). Sinusoidal diameter decreased and central venule or portal venule diameter respectively increased. Bile lakes (white arrow) were found in portal tracts in CBDL mice (d) (20×).