Table 2.
Tissues | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epithelium | Lumen | Smooth muscle cell (SMC) | Fibrovascular stroma | ||||||||||
Exp. groups | Post -treatment periods | Young | Adult | Old | Young | Adult | Old | Young | Adult | Old | Young | Adult | Old |
Control | 1 | 22.2 ± 0.71 | 18.8 ± 0.9a,1 | 26.1 ± 1.1a,1 | 19.6 ± 1.7a,1 | 49.9 ± 2.3a | 39.4 ± 1.7a | 26.0 ± 0.8a,1 | 12.8 ± 0.7a | 10.4 ± 0.4a,1 | 32.2 ± 1.6a,1 | 19.0 ± 1.5a | 23.6 ± 0.91 |
7 | 18.2 ± 0.7a,2 | 16.7 ± 0.7a,1,2 | 24.5 ± 0.91 | 26.8 ± 2.3a,1 | 49.5 ± 2.3a | 42.9 ± 1.2a | 23.6 ± 1.2a,1 | 11.8 ± 0.6a | 13.7 ± 0.5a,2 | 31.2 ± 1.6a | 22.0 ± 1.7a | 18.8 ± 0.9a,2 | |
14 | 18.9 ± 0.82 | 20.4 ± 1.3a,1 | 23.3 ± 0.91 | 34.4 ± 2.6a,2 | 50.9 ± 2.9a | 40.8 ± 1.5a | 20.2 ± 1.1a,2 | 12.1 ± 1.0a | 13.9 ± 0.6a,2 | 26.5 ± 1.6 | 16.9 ± 1.4a | 21.9 ± 0.9a,1 | |
21 | 21.3 ± 1.0a,1 | 22.0 ± 0.9a,1,3 | 22.1 ± 1.1a,2 | 21.3 ± 2.11 | 48.9 ± 2.0a | 39.1 ± 1.9a | 29.5 ± 1.3a,1,2 | 11.6 ± 0.6a | 14.1 ± 0.7a,2 | 27.8 ± 1.5a | 17.4 ± 1.2a | 24.3 ± 1.01 | |
Finasteride | 1 | 19.9 ± 0.91 | 19.6 ± 0.8a,1 | 25.5 ± 0.7a | 40.8 ± 1.5b,1 | 44.2 ± 2.1a,1 | 29.3 ± 1.6b,1 | 19.9 ± 0.8b,1 | 14.2 ± 0.9a,c,1 | 16.6 ± 0.7b | 19.4 ± 1.3b,1 | 22.3 ± 1.7a,b | 28.5 ± 1.31 |
7 | 20.1 ± 1.1a,b,1 | 26.3 ± 1.2b,2 | 23.6 ± 0.8 | 34.2 ± 2.2a,1 | 36.7 ± 2.4b,1 | 35.0 ± 1.4b,2 | 21.0 ± 1.3a,1 | 12.6 ± 0.6a,b | 16.8 ± 0.4b | 24.6 ± 1.3a,b,1 | 24.4 ± 1.6a | 24.8 ± 1.3b,1 | |
14 | 21.7 ± 0.81,2 | 18.8 ± 0.7a,1 | 24.4 ± 0.9 | 18.0 ± 1.5b,2 | 45.2 ± 1.9a,1 | 34.7 ± 1.2b,2 | 27.9 ± 0.9b,2 | 9.9 ± 0.7a,b,2 | 16.8 ± 0.4b | 32.2 ± 1.52 | 26.0 ± 1.8b | 23.9 ± 1.3a,b,2 | |
21 | 18.2 ± 0.9a,1,3 | 24.7 ± 0.9a,2 | 26.9 ± 1.1b | 20.2 ± 1.92 | 29.2 ± 2.6b,2 | 33.8 ± 1.1a,b,1 | 25.1 ± 1.3b,2 | 21.1 ± 7.1b,3 | 17.7 ± 0.6b | 36.4 ± 1.6a,2 | 23.8 ± 8.1b | 21.6 ± 0.92 | |
Letrozol | 1 | 23.0 ± 0.91 | 14.5 ± 0.9b,1 | 19.0 ± 1.0b,1 | 27.5 ± 2.3c,1 | 61.9 ± 1.7b,1 | 38.1 ± 2.3a | 22.5 ± 1.1b | 8.8 ± 0.3b,1 | 16.4 ± 0.8b,1 | 26.9 ± 1.5a,1 | 14.8 ± 1.0a,1 | 26.5 ± 1.61 |
7 | 22.5 ± 0.9b,1 | 19.0 ± 0.8a,2 | 22.9 ± 1.12 | 28.2 ± 2.6a,1 | 54.3 ± 2.2a,2 | 36.2 ± 1.6b | 19.1 ± 0.9b | 9.6 ± 0.7a,1 | 13.6 ± 0.6a,2 | 30.2 ± 2.0a,1 | 16.7 ± 1.3b,1 | 27.4 ± 1.0b,c,1 | |
14 | 19.6 ± 0.92 | 20.9 ± 0.8a,3 | 21.8 ± 1.11 | 32.1 ± 1.8a,1,2 | 47.2 ± 1.7a,3 | 43.1 ± 1.7a | 18.7 ± 1.0a | 11.9 ± 0.7a,2 | 13.6 ± 0.6a,2 | 29.5 ± 1.71 | 19.8 ± 1.1a,2 | 21.6 ± 0.8a,2 | |
21 | 20.4 ± 0.8a,1 | 22.9 ± 0.6a,3 | 21.2 ± 0.8a,1 | 22.3 ± 1.91,3 | 44.5 ± 1.7a,3 | 41.8 ± 1.8a,c | 21.9 ± 1.3b | 13.2 ± 0.7a,2 | 15.3 ± 0.8a,1 | 35.3 ± 2.1b,2 | 19.0 ± 1.3a,1 | 21.6 ± 1.02 | |
Fin + Let | 1 | 21.5 ± 0.81 | 20.8 ± 0.7a,1 | 21.5 ± 0.9b | 25.4 ± 1.1a,c,1 | 38.7 ± 1.6b,1 | 32.7 ± 1.8a,b,1 | 24.7 ± 0.9a,1 | 16.3 ± 1.0c,1 | 18.3 ± 0.8a,1 | 28.3 ± 1.5a,1 | 24.2 ± 1.1b | 28.2 ± 1.41 |
7 | 23.5 ± 1.2b,1 | 24.4 ± 0.8b,1 | 22.9 ± 0.8 | 11.9 ± 1.9b,2 | 35.0 ± 1.7b,1 | 29.2 ± 1.3c,1 | 28.3 ± 1.1c,1 | 14.6 ± 0.7b,1,2 | 17.1 ± 0.6a,c,2 | 36.6 ± 2.3a,c,2 | 25.9 ± 1.0a | 30.5 ± 1.1c,1 | |
14 | 21.8 ± 0.91 | 28.7 ± 0.7b,2 | 23.4 ± 0.7 | 16.2 ± 1.9b,3 | 31.2 ± 1.2b,2 | 34.3 ± 1.6b,1 | 31.4 ± 1.6b,2 | 14.0 ± 0.6a,c,1,2 | 15.6 ± 0.61 | 30.6 ± 1.41 | 26.1 ± 1.1b | 26.6 ± 1.4b,1 | |
21 | 16.3 ± 0.8b,2 | 28.3 ± 0.8b,2 | 22.3 ± 0.6a | 18.0 ± 1.33 | 31.1 ± 1.3b,2 | 40.4 ± 1.2a,c,2 | 24.5 ± 1.1b,1 | 18.3 ± 0.9b,1,3 | 14.1 ± 0.5a,2 | 41.1 ± 1.5b,2 | 22.5 ± 0.7b | 23.2 ± 1.42 |
Statistical analysis were based on anova and Tukey tests.
Alphabetic superindices (a, b, c) indicate statistically significant inter-group differences, when comparing treatment kind; numeric superindices (1, 2, 3) indicate statistically differences inter-group differences, when comparing stages of post-treatment period. Significant P ≤ 0.05. Comparisons among different postnatal ages where not executed.