Skip to main content
. Author manuscript; available in PMC: 2010 Apr 8.
Published in final edited form as: J Am Chem Soc. 2009 Apr 8;131(13):4685–4694. doi: 10.1021/ja808346y

Figure 7.

Figure 7

Reaction coordinate for the conversion from OMP to the products orotate and 5-phosphoribosyl 1-phophonoacetic acid (PRPA). The transition state structures of PfOPRT and HsOPRT are shown. MEP surfaces were generated by the CUBE subprogram of Gaussian 98 and visualized using Molekel 4.0 at a density of 0.2 electron/Å3.