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. Author manuscript; available in PMC: 2009 Dec 3.
Published in final edited form as: J Am Chem Soc. 2008 Dec 3;130(48):16358–16365. doi: 10.1021/ja807120z

Figure 1.

Figure 1

(a) Compound 1 and its desymmetrized analog 2. (b) Substrate metrics for bis(phenol) 1, defining a 5.75 Å distance between desired site of functionalization and prochiral stereogenic center (MM calculations). 9.79 Å span the enantiotopic hydroxyl groups. (c) Catalyst 4 effects enantioselective desymmetrization with high enantiomeric excess.