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. Author manuscript; available in PMC: 2009 Dec 3.
Published in final edited form as: J Am Chem Soc. 2008 Dec 3;130(48):16358–16365. doi: 10.1021/ja807120z

Table 1.

Peptide Results for First Three Libraries

graphic file with name nihms86556t1.jpg
Entry i i+1 i+2 i+3 i+4 i+5 1 (%) 3 (%) 5 (%) ee (%)
Library 1
1 Pmh Asn(Trt) Leu Val DPhe Phe 0.2 27.2 72.6 40
2 Pmh Phe Gly Leu Phe Phe 0.3 19.5 80.2 29
3 Pmh Dbg DPhe DPro Val Leu 4.7 46.3 49.0 28
4 Pmh Tyr(t-Bu) DPhe DHis(Trt) Tyr(t-Bu) Phe 0.2 16.2 83.6 25
5 Pmh Leu Aib Phe DVal Phe 0.2 12.1 87.7 23
6 Pmh Phe Gly Pro Phe Phe 0.4 18.4 81.2 21
7 Pmh Thr(t-Bu) DPro Ser(t-Bu) Phe Phe 0.5 30.4 69.1 21
Library 2
8 Pmh Asn(Trt) Leu Thr(t-Bu) DPhe Phe 0.1 25.4 74.5 49
9 Pmh Asn(Trt) Leu Ser(t-Bu) DPhe Phe 0.2 27.3 72.5 47
10 Pmh Asn(Trt) Leu Ala DPhe Phe 0.2 14.7 85.1 43
11 Pmh Asn(Trt) Aib Val DPhe Phe 0.2 20.2 79.6 41
12 Pmh Asn(Trt) Dbg Val DPhe Phe 0.2 17.8 82.0 39
13 Pmh Asn(Trt) Leu Val DPhe DPhe 0.2 15.6 84.2 38
14 Pmh Asn(Trt) Ala Val DPhe Phe 0.2 70.6 29.2 32
Library 3
15 Pmh DAsp(Ot-Bu) Leu Thr(t-Bu) DPhe Phe 1.3 25.0 73.7 42
16 Pmh DAsp(Ot-Bu) Leu Ser(t-Bu) DPhe Phe 0.2 16.6 83.2 42
17 Pmh Asp(OBzl) Leu Val DPhe Phe 0.2 9.4 90.4 40
18 Pmh Asn(Trt) Leu Tle DPhe Phe 0.1 25.4 74.5 36
19 Pmh Asn(Trt) Leu Val DVal Phe 0.4 40.0 59.6 34
20 Pmh DAsp(Ot-Bu) Leu Val DPhe Phe 0.3 16.6 83.1 32