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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Exp Parasitol. 2008 Dec 25;122(1):28–36. doi: 10.1016/j.exppara.2008.12.010

Figure 6.

Figure 6

Hypothetical signal transduction scheme involving PI3K/Akt and MAP kinase signaling that controls IL-12 production in L. amazonensis-infected macrophages. Akt activation differentially modulates ERK and p38 activation; whereas inhibition of PI3K/Akt results in the induction of p38, Akt inhibition suppresses ERK activation. Given that IL-12 suppression is not relieved upon ERK inhibition, it is unlikely that ERK is directly downstream of Akt. Although p38 is negatively regulated by Akt, its induction is independent of PI3K activation.