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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Neuropsychopharmacology. 2008 Oct 15;34(6):1406–1415. doi: 10.1038/npp.2008.154

Figure 5.

Figure 5

Effect of i.c.v. CRF-R antagonist (d-phe-CRF) treatment unspecific for receptor type 1 and 2 on passive stress-coping in (a) the forced swim test, (b) the tail suspension test, and (c) the partner preference test in female-paired male voles from Experiment D (see Figure 1 for details). Male voles were group-housed for 5 days with a female and constantly infused with CRF-A the following days while being still with the partner (grey bars) or separated 3–5 days (black bars). The amount of time the animals spend on passive stress-coping strategy, ie floating (a) or immobility (b). The partner preference (c) is represented by the time the male voles spent on huddling with either a female stranger or the bonding partner. Numbers of animals included in the statistics were paired VEH: 5; CRF-A: 4; separated VEH: 7; CRF-A: 6. Data are expressed as mean + SEM. **p0.01 vs all other groups. *p<0.05 vs huddling with stranger in same group.