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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Neuropsychopharmacology. 2008 Oct 15;34(6):1406–1415. doi: 10.1038/npp.2008.154

Figure 6.

Figure 6

Effect of i.c.v. CRF-R1 (CP-154526) or CRF-R2 (Astressin-2B) antagonist treatment on passive stress-coping in (a) the forced swim test and (b) the tail suspension test in female-paired male voles from Experiment E (see Figure 1 for details). Male voles were group-housed for 5 days with a female and constantly infused with CRF-R1 or -R2 antagonist the following days when still with the partner (grey bars) or separated 3–4 days (black bars). The amount of time the animals spend on passive stress-coping strategy is reflected as floating (a) or immobility (b). Numbers of animals included in the statistics were paired VEH: 10; CRF-R1: 9; CRF-R2: 9; separated were 10 per group. Data are expressed as mean + SEM. **p<0.01 vs respective female-paired group; ##p<0.01, #p<0.05 vs vehicle-treated separated group.