Table 2.

Metabolite Levels in Basal Ganglia Voxel: Means and Standard Deviations

	NAA	Cho	Glu	Glx	tCr	Tau	mI
MRS 1
Relative to tissue water
EtOH	0.349±0.043	0.362±0.040	0.087±0.017	0.094±0.019	0.353±0.048	0.063±0.019	0.084±0.018
Ctrl	0.348±0.033	0.341±0.013	0.079±0.016	0.091±0.018	0.345±0.024	0.063±0.011	0.081±0.010
Relative to tCr
EtOH	0.989±0.027	1.03±0.065	0.245±0.036	0.264±0.028	1	0.179±0.058	0.239±0.044
Ctrl	1.01±0.053	0.993±0.051	0.229±0.036	0.262±0.043	1	0.183±0.026	0.236±0.026
MRS 2
Relative to tissue water
EtOH	0.324±0.019	0.383±0.026*	0.074±0.011	0.101±0.015*	0.320±0.022	0.059±0.015	0.087±0.013
Ctrl	0.333±0.026	0.341±0.014	0.066±0.011†	0.089±0.015	0.338±0.018	0.065±0.012	0.084±0.008
Relative to tCr
EtOH	1.013±0.041	1.199±0.098*,†	0.231±0.034*	0.316±0.047*,†	1	0.186±0.049	0.273±0.046†
Ctrl	0.987±0.049	1.011±0.051	0.196±0.030†	0.264±0.046	1	0.192±0.040	0.248±0.030
MRS 3
Relative to tissue water
EtOH	0.323±0.027	0.407±0.040*,‡	0.091±0.015*	0.109±0.015*	0.317±0.022	0.056±0.012	0.082±0.007*,*
Ctrl	0.338±0.035	0.341±0.036	0.075±0.013	0.089±0.013	0.337±0.025	0.068±0.015	0.095±0.013‡
Relative to tCr
EtOH	1.019±0.054	1.284±0.089*,‡,#	0.287±0.041*,#	0.346±0.047*,‡	1	0.177±0.029	0.261±0.028
Ctrl	1.006±0.114	1.009±0.077	0.224±0.042	0.265±0.037	1	0.202±0.037	0.282±0.024‡#

Abbreviations: Ctrl, control group; EtoH, ethanol group; NAA, N-acetylaspartate; Glu, glutamate; Cho, choline; mI, myo-inositol; Glx, glutamine+glutamate; tCr, total creatine; Tau, taurine; MRS, magnetic resonance spectroscopy; EtOH, n=8; Ctrl, n=10.

^*p<0.05 between EtOH and Ctrl, one-tailed,

^**two-tailed.

^†p<0.05 between MRS 1 and MRS 2, two-tailed.

^‡p<0.05 between MRS 1 and MRS 3, two-tailed.

^#p<0.05 between MRS 2 and MRS 3, two-tailed.