Table 1. Gene ontology (GO) analysis of expression profiles of long-lived mutants.
| Positively affected GO categories | sch9Δ | tor1Δ | ras2Δ | ||||||
| GO * | GO ID | Gene # | Annotation | p | q | p | q | p | q |
| C | GO:0005842 | 93 | cytosolic large ribosomal subunit | 0.00E+00 | 0.00E+00 | 0.00E+00 | 0.00E+00 | 1.64E-12 | 2.37E-10 |
| C | GO:0005843 | 63 | cytosolic small ribosomal subunit | 0.00E+00 | 0.00E+00 | 0.00E+00 | 0.00E+00 | 7.49E-09 | 6.49E-07 |
| P | GO:0016125 | 37 | sterol metabolism | 5.65E-03 | 6.20E-02 | 7.50E-03 | 7.56E-02 | 7.51E-05 | 2.32E-03 |
| P | GO:0046365 | 33 | monosaccharide catabolism | 1.32E-03 | 2.01E-02 | 2.94E-05 | 1.02E-03 | 8.81E-06 | 3.81E-04 |
| Negatively affected GO categories | sch9Δ | tor1Δ | ras2Δ | ||||||
| GO * | GO ID | Gene # | Annotation | p | q | p | q | p | q |
| C | GO:0005762 | 43 | mitochondrial large ribosomal subunit | 1.56E-19 | 3.32E-17 | 1.13E-20 | 4.29E-18 | 1.34E-20 | 4.29E-18 |
| C | GO:0005763 | 34 | mitochondrial small ribosomal subunit | 6.94E-13 | 4.93E-11 | 3.17E-13 | 2.54E-11 | 4.83E-14 | 4.41E-12 |
| C | GO:0016591 | 74 | DNA-directed RNA polymerase II, holoenzyme | 1.61E-05 | 2.29E-04 | 9.05E-05 | 8.65E-04 | 4.97E-10 | 2.27E-08 |
| C | GO:0000502 | 46 | proteasome complex | 3.92E-04 | 2.56E-03 | 4.51E-03 | 1.72E-02 | 1.35E-08 | 4.79E-07 |
| C | GO:0005743 | 158 | mitochondrial inner membrane | 2.64E-16 | 2.82E-14 | 3.56E-17 | 5.70E-15 | 3.14E-09 | 1.34E-07 |
| F | GO:0008080 | 37 | N-acetyltransferase activity | 6.89E-03 | 2.32E-02 | 6.43E-03 | 2.25E-02 | 3.16E-04 | 2.20E-03 |
| P | GO:0016570 | 59 | histone modification | 1.56E-03 | 7.85E-03 | 2.16E-04 | 1.64E-03 | 7.30E-06 | 1.14E-04 |
| P | GO:0006365 | 67 | 35S primary transcript processing | 1.93E-03 | 9.16E-03 | 3.84E-06 | 7.23E-05 | 4.05E-03 | 1.59E-02 |
| P | GO:0007005 | 95 | mitochondrion organization and biogenesis | 6.62E-05 | 7.02E-04 | 1.32E-04 | 1.07E-03 | 4.51E-06 | 8.02E-05 |
| P | GO:0016044 | 31 | membrane organization and biogenesis | 2.09E-03 | 9.85E-03 | 1.38E-03 | 7.18E-03 | 9.74E-03 | 3.06E-02 |
| P | GO:0006626 | 47 | protein-mitochondrial targeting | 8.33E-06 | 1.27E-04 | 1.46E-06 | 3.11E-05 | 4.04E-04 | 2.59E-03 |
| P | GO:0009060 | 82 | aerobic respiration | 2.66E-08 | 8.96E-07 | 4.73E-09 | 1.78E-07 | 1.32E-06 | 3.01E-05 |
| P | GO:0006119 | 46 | oxidative phosphorylation | 7.03E-07 | 2.04E-05 | 9.01E-07 | 2.31E-05 | 1.57E-04 | 1.24E-03 |
| P | GO:0006118 | 31 | electron transport | 1.22E-04 | 1.03E-03 | 1.01E-04 | 9.28E-04 | 4.29E-03 | 1.65E-02 |
Significantly up-or down-regulated categories were shown in bold (p<0.01). q-value was also calculated to correct the multi-testing error.
*: GO categories: C, Cellular component; F, molecular function; and P, biological process.