Skip to main content
. Author manuscript; available in PMC: 2009 Dec 25.
Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):7921–7932. doi: 10.1021/jm8010299

Figure 1.

Figure 1

(a) Type II inhibitors induce, stabilize, and exploit a distinct “DFG-out” conformation of the target kinases. (b) Conformational statistics of mammalian structural kinome (based on PDB release of June 2008).