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. Author manuscript; available in PMC: 2009 Dec 25.
Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):7921–7932. doi: 10.1021/jm8010299

Figure 2.

Figure 2

DOLPHIN transformation: (a) DFG Phe and the four next residues in the sequence are removed; (b) attractive density is generated from selected removed atoms. The transparent blobs represent equipotent contours of the lipophilic (dark-blue) and polar (sea-green) parts of the density; (c) this computational “surgery” dramatically affects the ligand binding pocket shape and size, producing a type-II compatible model.