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. 2009 Mar 24;52(8):2185–2187. doi: 10.1021/jm801654y

Table 2. Inhibition of pfHDAC-1 Activity and P. falciparum 3D7 Proliferation by Known HDAC Inhibitors.

  IC50 (nM)
compd pfHDAC-1 P. falciparum 3D7
3 0.6 ± 0.1 16 ± 7
4 59 ± 6 210 ± 30
5 1.8 ± 0.2 21 ± 3
6 940 ± 90 >10000
7 1 ± 0.1 33 ± 5
splitomicin >10000 >10000