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. Author manuscript; available in PMC: 2009 Apr 16.
Published in final edited form as: AIDS Res Hum Retroviruses. 2004 Oct;20(10):1063–1071. doi: 10.1089/aid.2004.20.1063

FIG. 2.

FIG. 2

Effect of SDF-1α and gp120IIIB on ERK and JNK. (A) SDF-1α (20 nM) and gp120IIIB (200 pM) stimulate ERK phosphorylation in CXCR4+/CD4− HOS cells. Cells treated with gp120 in the presence of soluble hCD4 show a more rapid and transient phosphorylation of ERK as compared to gp120 alone. The graph indicates the densitometric analysis from three independent experiments. As in these cells the p42 ERK band is much more evident than the p44 band; it has always been used for densitometric analysis. (B) SDF-1α and gp120IIIB stimulate JNK phosphorylation in CXCR4+/CD4− HOS cells in a dose- and time-dependent manner. The graph shows the analysis of three independent experiments (15 min treatments).