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Phosphorylation of MAP kinases induced by SDF-1α or gp120IIIB is mediated by CXCR4 in human astrocytes. The CXCR4 antagonist, AMD3100 (200 ng/ml), is able to block the ERK (A) and JNK (B) activation by SDF-1α (2 nM) or gp120IIIB (200 pM). The graphs show the analysis of three independent experiments normalized with total ERK or JNK, respectively.
