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The calcineurin-NFAT signaling module works through dephosphorylation of NFAT and its nuclear translocation into the nucleus to bind the IL-2 promoter. In contrast, the MEF2-Cabin1/class II HDAC signaling module operates via calmodulin-dependent release of Cabin1 or class II HDACs from MEF2, making room for association by p300 (See Fig. 5 for more detail).
