Table 1.

. Effect of DOCA-Salt Treatment on Body Weight, Heart Weight, Kidney Weight, Plasma and Urine Chemistries in WT and TRPV1^-/- Mice

Parameters	WT	TRPV1-/-	DOCA-WT	DOCA-TRPV1-/-
Body Weight (g)	28.1±0.4	28.7±0.3	28.5±0.4	29.4±0.4
Heart Weight (mg/10 g BW)	43.9±1.4	44.6±1.7	58.2±2.1*	59.9±2.4*
Kidney Weight (mg/10 g BW)	78.9±1.3	75.8±1.2	111.5±3.4*	115.2±3.1*
Plasma [K+] (mmol/L)	6.3±0.4	6.0±0.5	5.9±0.3	5.7±0.5
Plasma [Na+] (mmol/L)	148±4	152±3	149±2	150±5
Urinary Output (ml/24 h)	1.6±0.2	1.4±0.3	18.1±2.3*	12.5±1.4*
Urinary Albumin (μg/24 h)	5.8±0.7	6.5±0.9	26.6±2.8*	74.8±4.5*†
Urinary 8-Isoprostane (ng/24 h)	0.52±0.11	0.60±0.10	1.27±0.19*	2.64±0.38*†
Creatinine Clearance (ml/24 h)	344±23	334±25	206±17*	114±19*†

Values are means ± SE; n = 7-8 mice. DOCA, deoxycorticosterone acetate; WT, wild type; TRPV1^-/-, the transient receptor potential vanilloid type 1 receptor-null mutant; DOCA-WT, WT mice treated with DOCA-salt; DOCA-TRPV1^-/-, TRPV1^-/- mice treated with DOCA-salt; BW, body weight.

^*P<0.05 compared with control WT or TRPV1^-/- mice

^†P<0.05 compared with DOCA-WT mice.