Table 1.
Parameters | Sham |
3 Days after MI |
7 Days after MI |
|||
---|---|---|---|---|---|---|
WT | TRPV1-/- | WT | TRPV1-/- | WT | TRPV1-/- | |
n | 16 | 16 | 9 | 8 | 8 | 8 |
Body weight | 27.4 ± 0.5 | 27.9 ± 0.6 | 27.3 ± 0.6 | 27.6 ± 0.7 | 28.0 ± 0.5 | 28.2 ± 0.6 |
HR | 397 ± 27 | 392 ± 29 | 394 ± 28 | 387 ± 26 | 364 ± 29 | 396 ± 30 |
PWthd, (mm) | 0.72 ± 0.06 | 0.73 ± 0.05 | 0.78 ± 0.07 | 0.82 ± 0.08* | 0.87 ± 0.09* | 0.98 ± 0.07*†‡ |
PWths, (mm) | 1.31± 0.05 | 1.34 ± 0.07 | 1.40 ± 0.12 | 1.49 ± 0.15* | 1.70 ± 0.11*‡ | 1.92 ± 0.12*†‡ |
LVIDd, (mm) | 3.1 ± 0.17 | 3.2 ± 0.18 | 4.02 ± 0.26* | 4.75 ± 0.29*† | 4.52 ± 0.25*‡ | 5.2 ± 0.28*†‡ |
LVIDs, (mm) | 2.3 ± 0.19 | 2.4 ± 0.16 | 2.99 ± 0.28* | 4.02 ± 0.25*† | 3.76 ± 0.24*‡ | 4.46 ± 0.27*†‡ |
% EF | 58.5 ± 3.2 | 57.8 ± 3.4 | 50.4 ± 3.6* | 32.9 ± 3.4*† | 42.6 ± 3.8*‡ | 27.0 ± 3.5*†‡ |
Data are expressed as mean ± SEM. HR, Heart rate; BW, body weight; PWthd, posterior wall thickness in diastole; PWths, posterior wall thickness in systole; LVIDd, left ventricle internal diameter in diastole; LVIDs, left ventricular internal diameter in systole; EF, left ventricular ejection fraction
P<0.05 vs sham
P<0.05 vs. WT
P<0.05 vs. corresponding day 3