Table 3. Two-Step Syntheses of Macrolactones Based on the Cascade Coupling Reaction.

^aReaction conditions: 5% (^tBu₃P)AuCl/AgSbF₆, CH₂Cl₂, rt.

^bRCM conditions A: 10% 6, CH₂Cl₂, rt, 4 h. B: 10% 7, CH₂Cl₂, reflux, 24 h. C: 10% 8, CH₂Cl₂, reflux, 6−24 h; D: 10% 9, CH₂Cl₂, reflux, 24 h.

^cIsolated yield.

^dReaction conditions: 5% (IMes)AuCl/AgSbF₆, CH₂Cl₂, rt.

^eRCM conditions D.