Table 3.
Overall Chemotherapy and Acute Radiotherapy Toxicity (Grade 1 to 4) by Treatment Arm
| Toxicity | FU-Based Arm 1 (n = 28), Grade |
Non–FU-Based Arm 2 (n = 45), Grade |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
2 |
3 |
4 |
1 |
2 |
3 |
4 |
|||||||||
| No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | |
| Allergy/immunology | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | ||||||||
| Auditory/hearing | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | ||||||||
| Blood/bone marrow | 4 | 4 | 6 | 13 | 6 | 9 | 13 | 5 | ||||||||
| Cardiovascular (arrhythmia) | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | ||||||||
| Cardiovascular (general) | 0 | 3 | 4 | 2 | 3 | 0 | 4 | 1 | ||||||||
| Coagulation | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | ||||||||
| Constitutional symptoms | 6 | 13 | 4 | 0 | 11 | 24 | 5 | 0 | ||||||||
| Dermatology/skin | 3 | 7 | 1 | 0 | 5 | 9 | 0 | 0 | ||||||||
| Endocrine | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||||
| Gastrointestinal | 0 | 7 | 18 | 1 | 7 | 19 | 12 | 3 | ||||||||
| Hemorrhage | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | ||||||||
| Hepatic | 8 | 2 | 0 | 0 | 6 | 6 | 3 | 0 | ||||||||
| Infection/febrile neutropenia | 1 | 0 | 5 | 1 | 1 | 1 | 8 | 0 | ||||||||
| Metabolic/laboratory | 7 | 3 | 4 | 0 | 12 | 8 | 5 | 1 | ||||||||
| Musculoskeletal | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | ||||||||
| Neurology | 5 | 5 | 0 | 1 | 13 | 4 | 6 | 0 | ||||||||
| Ocular/visual | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | ||||||||
| Pain | 4 | 3 | 3 | 0 | 9 | 6 | 5 | 0 | ||||||||
| Pulmonary | 2 | 1 | 1 | 0 | 5 | 8 | 1 | 0 | ||||||||
| Renal/genitourinary | 1 | 0 | 0 | 0 | 5 | 3 | 0 | 0 | ||||||||
| Worst GI | 0 | 7 | 25 | 18 | 64 | 1 | 4 | 7 | 16 | 19 | 42 | 12 | 27 | 3 | 7 | |
| Worst hematologic | 4 | 14 | 4 | 14 | 6 | 21 | 13 | 46 | 6 | 13 | 9 | 20 | 13 | 29 | 5 | 11 |
| Worst overall | 0 | 1 | 4 | 12 | 43 | 15 | 54 | 2 | 4 | 8 | 18 | 23 | 51 | 10 | 22 | |
NOTE. Scored using National Cancer Institute Common Toxicity Criteria Version 2.0.
Abbreviation: FU, fluorouracil.