Table 4.

Relationship of Stroke and Time of Follow-up to Memory, Abstract/visuospatial and Language Performance in 1271 Elderly Persons Over 7 years of Follow-up stratified by APOE genotype.

	Model 1		Model 2
Variable	Estimated β (SE)	p-value	Estimated β (SE)	p-value
Memory Performance
-/- APOEε4 genotype
Time	-1.3 (0.7)	0.06	-1.7 (0.8)	0.04
Stroke	-1.5 (7.3)	0.8	3.4 (8.4)	0.7
Time*Stroke	-4.1 (2.2)	0.07	-4.2 (2.4)	0.09
-/4 or 4/4 APOEε4 genotype
Time	-2.5 (1.1)	0.02	-3.2 (1.2)	0.008
Stroke	-3.4 (10.8)	0.8	-1.3 (14.0)	0.9
Time*Stroke	-2.6 (2.9)	0.4	-1.4 (3.2)	0.6
Abstract/visuospatial Performance
-/- APOEε4 genotype
Time	1.0 (3.5)	0.8	3.8 (4.1)	0.4
Stroke	-0.1 (3.1)	0.9	-0.1 (0.3)	0.9
Time*Stroke	-1.1 (0.5)	0.04	-1.0 (0.6)	0.06
-/4 or 4/4 APOEε4 genotype
Time	0.4 (0.4)	0.4	0.4 (0.4)	0.4
Stroke	-6.7 (4.7)	0.1	-3.3 (6.0)	0.6
Time*Stroke	1.7 (1.1)	0.1	2.0 (1.0)	0.07
Language Performance
-/- APOEε4 genotype
Time	0.1 (0.1)	0.8	-0.1 (0.1)	0.9
Stroke	-0.1 (0.6)	0.9	0.3 (0.6)	0.6
Time*Stroke	0.1 (0.1)	0.2	0.1 (0.1)	0.2
-/4 or 4/4 APOEε4 genotype
Time	-0.1 (0.1)	0.8	-0.1 (0.1)	0.8
Stroke	-0.4 (0.8)	0.6	0.1 (0.8)	0.9
Time*Stroke	-0.1 (0.2)	0.8	-0.1 (0.3)	0.7

Model 1 is adjusted for age and gender, Model 2 is adjusted for age, gender, education, ethnic group, BMI, hypertension, heart disease, diabetes and smoking