Figure 3.

Characteristics of CD8⁺ T human lymphocytes specific for cytomegalovirus (CMV; top panel), influenza virus (Flu; second panel) Epstein–Barr virus (EBV; third and fourth panels) and human immunodeficiency virus (HIV; bottom panel). (a) Four representative individuals are presented. The majority of CMV-specific cells were CD26^low, CD28⁻, CCR7⁻ and enriched in CD27⁻, CD127⁻, KLRG1⁺ and CD57⁺ cells. Similar CD26 expression was obtained for the two EBV epitopes studied, as well as for HIV. Conversely, influenza-virus-specific cells were a majority of CD26⁺, CD27⁺, CD127⁺, CD57⁻, and enriched in CD28⁺ and KLRG1⁻ cells. Gated on unstimulated CD8⁺ CD3⁺ T cells. (b) Focus on CD26 expression on different virus-specific CD8⁺ human T cells.