Table 3.

Types of mutations by smoking status for the Discovery screen. P values for differences between smokers and non-smokers, adjusting for age and gender.

	Non-smokers N = 13	Smokers N = 11	P
	Mean SD	Mean SD
Mutations	56.2 (13.9)	75.5 (41.7)	0.06
Mutations not in KRAS, TP53, SMAD4 or CDKN2A/P16	53.9 (14.1)	73.5 (41.7)	0.05
Mutations not in any driver gene	53.2 (13.8)	73.3 (41.8)	0.05
Synonymous Mutations	14.8 (5.4)	18.7 (11.3)	0.26
Non-synonymous Mutations	38.5 (11.1)	53.1 (27.9)	0.04
Transition Mutations	35.3 (9)	43.7 (16.9)	0.04
Transversion Mutations	20.9 (10.3)	31.8 (25.9)	0.16