Table 4.

Frequency of specific sequence mutations and context for the Discovery Screen, by smoking status. Odds ratios for having each specific type of mutation for smokers v. non-smokers, adjusting for age and gender.

	Number of mutations in non-smokers	Number of non-smokers with a specific mutation	Number of mutations in smokers	Number of smokers with a specific mutation	Odds Ratio [95% C.I.]	P
Sequence Mutations
A to C	26	10	22	10	0.72 [0.33,1.54]	0.40
A to G	32	12	50	11	1.38 [0.86,2.21]	0.18
A to T	20	9	29	11	1.25 [0.69,2.27]	0.46
C to A	36	13	70	10	1.6 [1.04,2.46]	0.03
C to G	34	11	34	10	0.76 [0.45,1.26]	0.28
C to T	214	13	197	11	0.78 [0.57,1.07]	0.13
G to A	187	13	200	11	1.02 [0.79,1.31]	0.89
G to C	39	9	35	10	0.8 [0.36,1.76]	0.57
G to T	57	13	83	11	1.27 [0.88,1.85]	0.20
T to A	8	6	20	8	2.32 [0.99,5.45]	0.05
T to C	26	11	34	8	1.15 [0.64,2.06]	0.63
T to G	15	8	16	7	0.85 [0.41,1.79]	0.68
Insertion or Deletion	37	13	41	11	1.01 [0.63,1.63]	0.96
Context
A	78	13	101	11	1.07 [0.78,1.48]	0.66
C	90	13	104	11	0.91 [0.67,1.25]	0.57
C*pG	152	13	140	11	0.82 [0.6,1.12]	0.21
CpG*	128	13	143	11	1.16 [0.8,1.69]	0.43
G	92	13	119	11	1.11 [0.82,1.5]	0.49
G*pA	63	12	56	11	0.79 [0.41,1.53]	0.49
T	49	12	70	11	1.25 [0.81,1.92]	0.31
TpC*	42	12	57	10	1.16 [0.76,1.77]	0.49
All Sequence Mutations	731	13	831	11	1.26 [0.74,2.15]	0.40