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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Invest Dermatol. 2008 Nov 13;129(5):1174–1184. doi: 10.1038/jid.2008.349

Figure 1. Schematic diagram of genomes of HSV-1 recombinant CJ9-gD.

Figure 1

UL and US represent the unique long and unique short regions of the HSV-1 genome, respectively, which are flanked by their corresponding inverted repeat regions (open boxes). A. The replacement of the ICP0 coding sequences with DNA sequences encoding the DNA binding domain of UL9, UL9-C535C (black box), under control of the tetO-bearing hCMV major immediate-early promoter (vertical line box) in CJ83193 is shown above the diagram of the HSV-1 genome. An expanded UL9 ORF from UL9 locus is shown below the diagram. B. CJ9-gD was generated by replacing the Xcm I - Mlu I fragment encoding UL9 amino acids 217 to 803 within the UL9 ORF in CJ83193 with the HSV-1 gD gene under control of the tetO-bearing hCMV immediate-early promoter. The gradient box shows the poly A signal sequence of bovine growth hormone gene.