Table 2.
Utility values and miscellaneous risks and costs used to specify Monte Carlo simulation in decision analytical model
| Condition | Value* | Standard error (95% CI) | Source | Assigned distribution |
|---|---|---|---|---|
| Utility values | ||||
| Health states: | ||||
| Remission | 1.00 | 0 | Kok et al15 | Beta |
| No remission | 0.94 | 0.009 (0.92 to 0.96) | Kok et al15 | Beta |
| Incontinence | 0.89 | 0.006 (0.88 to 0.91) | Ackerman et al16 | Beta |
| Adverse effects†: | ||||
| Urinary retention | 0.89 | 0.012 (0.87 to 0.92) | Ackerman et al16 | Beta |
| Bladder neck stenosis | 0.95 | 0.001 (0.95 to 0.96) | Ackerman et al16 | Beta |
| Urinary tract infection | 0.93 | 0.004 (0.92 to 0.94) | Ackerman et al16 | Beta |
| Transurethral resection syndrome | 0.81 | 0.022 (0.77 to 0.85) | Ackerman et al16 | Beta |
| Miscellaneous variables | ||||
| Risks: | ||||
| Transurethral resection after urinary retention | 0.5 | 0.05 (0.40 to 0.6) | Expert opinion | Beta |
| Urge type incontinence | 0.95 | 0.02 (0.91 to 0.99) | Expert opinion | Beta |
| Costs: | ||||
| Baseline treatment (including mean length of stay) (£) | 1862 | (1546 to 2195)‡ | NHS 200617 | Lognormal |
| Urology ward bed day (£) | 250 | (141 to 443)‡ | NHS 200617 | Lognormal |
| Length of stay after transurethral resection syndrome (days) | 2 | 0.51 (1 to 3) | Expert opinion | Normal |
| Length of stay after urinary infection (days) | 3 | 1.4 (0.25 to 5.75) | Expert opinion | Normal |
| Urodynamic test (£) | 125 | 16 (92 to 157) | NHS 200517 | Normal |
| Transfusion (£) | 1270 | 323 (635 to 1905) | NHS tariff | Normal |
| Oxybutynin (£) | 166 | (65 to 267)§ | NHS drug tariff | Uniform |
*Risk unless otherwise stated.
†Age adjusted mortality rates estimated from UK life tables and applied equally throughout time horizon without weighting according to procedure.
‡Where log distributions have been used, standard error is omitted to avoid inconsistency with confidence interval, which is expressed as actual relative risk.
§Limits of uniform distribution.