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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Prostate. 2009 May 1;69(6):633–643. doi: 10.1002/pros.20916

Figure 4.

Figure 4

Immunostaining for chemoattractant receptor CXCR4 and adhesion molecules (VCAM1) in representative samples of prostates from C57BL/6J mice. IL-1β (10 μg/kg) was i.v. injected in the tail vein. To proof pro-inflammatory ability of IL-1β along with NF-κB activation in prostate tissue, some animals were i.p. injected with dexamethasone (Dex) (10 mg/kg) one hour before IL-1β administration. The animals were sacrificed at 4, 8, and 24 h after cytokine administration. Up-regulation of CXCR4 expression in prostate tissue and leukocytes was detected at all three time points after IL-1β treatment and was super-induced by Dex (arrowhead). Focal VCAM1 stained capillary's endothelium was observed only at 24 h (red arrowhead). Dex pretreatment was able significantly reduce IL-1β-dependent VCAM1 expression in mouse prostate.