TABLE-1.
NF-κB/p65 | CXCR1/IL-8RA | IL-17F | VCAM1 | CXCR4 | ||||||
---|---|---|---|---|---|---|---|---|---|---|
IL-1β | IL-1β + DEXb | IL-1β | IL-1β + DEX | IL-1β | IL-1β + DEX | IL-1β | IL-1β + DEX | IL-1β | IL-1β + DEX | |
4 hra | +++ | + | ++ | − | + | + | − | − | + | + |
8 hr | ++ | + | +++ | − | ++ | + | − | − | + | ++ |
24 hr | + | − | − | − | +++ | − | + | − | ++ | +++ |
Note:
time after mouse rIL-1β i.v. administration (10 μg/kg)
dexamethasone (10 mg/kg) was injected i.p. one hour before IL-1β administration
DEX – dexamethasone; + − low; ++ − mild; and +++ − high expression of markers studied in prostate tissue and/or intraprostatic mononuclear cells. VCAM1 – vascular cell adhesion molecule – 1; CXCR1 and 4 - chemokine (C-X-C motif) receptor – 1 and 4; IL-8RA – IL-8 receptor alpha.