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. Author manuscript; available in PMC: 2009 Apr 17.
Published in final edited form as: Nat Genet. 2007 Dec 2;40(1):90–95. doi: 10.1038/ng.2007.40

Figure 3. Male meiotic rates of deletions and duplications caused by NAHR.

Figure 3

The histogram shows the estimated rates of de novo NAHR for eight rearrangement hotspots, each assayed in 5 sperm donors. Nine sperm donors (C, D, E, F, G, H, K, L and N) were studied overall, but for each pair of reciprocal deletion and duplication the same 5 donors were assayed. Error bars represent 95% confidence limits for each rate estimate. For comparison with birth prevalence of their associated disorders, these NAHR rates need to be scaled to take account of NAHR events that occur outside the hotspot, and sex-biases in NAHR rates (see Supplementary Note for more details).