Table 2.
Allopurinol group n = 85 | Placebo group n = 85 | P | |
Procedural details | |||
Total procedural time (min) | 37.8 ± 11.9 | 38.2 ± 12.4 | 0.82 |
Cannulation time (min) | 15.4 ± 5.5 | 15.6 ± 5.6 | 0.81 |
Pancreatic cannulation and injection | 24 (24.7) | 18 (21.1) | 0.18 |
Number of injections | 1.23 ± 0.42 | 1.27 ± 0.44 | 0.60 |
Acinarization | 9 (10.5) | 9 (10.5) | 0.58 |
Invasive diagnostics | |||
Cytology | 15 (17.6) | 17 (20) | 0.42 |
Intrabiliary biopsy | 2 (2.3) | 2 (2.3) | 0.69 |
Therapeutics | |||
Any Therapeutics | 71 (83.5) | 74 (87) | 0.51 |
Precut sphincterotomy | 15 (17.6) | 18 (21.1) | 0.56 |
Biliary sphincterotomy | 20 (23.5) | 17 (20) | 0.57 |
Stone extraction | 29 (34.1) | 27 (31.7) | 0.74 |
Biliary stenting | 32 (37.6) | 37 (43.5) | 0.43 |
Pancreatic stenting | 2 (2.3) | 3 (3.5) | 0.64 |
End points | |||
Hyperamylasemia | 5 (5.8) | 18 (21.1) | 0.003 |
Pancreatitis | 2 (2.3) | 8 (9.4) | 0.049 |
PEP in low-risk procedures | 1/55 (1.8) | 1/57 (1.7) | 0.70 |
PEP in high-risk procedures | 1/30 (3.3) | 7/28 (25) | 0.02 |
ERCP morbidity | |||
Bleeding | 2 (2.3) | 2 (2.3) | 0.69 |
Perforation | 1 (1.1) | 0 | 0.50 |