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. Author manuscript; available in PMC: 2009 Apr 17.
Published in final edited form as: J Neurosci Methods. 2004 Dec 8;144(1):25–34. doi: 10.1016/j.jneumeth.2004.10.016

Fig. 3.

Fig. 3

Dual-probe microdialysis measures of ECF DA with simultaneous microPET assay of 11C-raclopride time activity following a cold raclopride infusion into the ipsilateral striatum. Circles depict the time activity of 11C-raclopride (open) and extracellular DA (filled) in the striatum ipsilateral to an infusion of 45 nmol raclopride (corrected for probe permeability). Squares represent 11C-raclopride binding (open) and extracellular DA (filled) in the contralateral, control striatum. Triangles give the time activity of cerebellar 11C-raclopride. Time-activity data were fit to a tri-exponential model as described in the text. Inset: Top image captures 11C-raclopride microinfusion (∼50 μCi/probe) immediately following the study, the middle image depicts the distribution of 11C-raclopride at the level of the striatum. The two images are co-registered with PMOD software on the bottom. Right is right in the image.