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. Author manuscript; available in PMC: 2009 Apr 17.
Published in final edited form as: J Neurovirol. 2004;10(Suppl 1):108–112. doi: 10.1080/753312761

Figure 1.

Figure 1

Simplified model for the involvement of cell cycle proteins in the regulation of survival and differentiation by neuronal chemokine receptors: SDF-1α may affect expression of survival genes by regulating Rb and E2F-1 function. Also, SDF-1α could affect the interaction of Rb and/or E2F-1 with additional proteins involved in the regulation of cell survival (i.e., mdm2, Akt and MAP kinases). Thus, alterations of the CDK/Rb/E2F pathway—induced by activation of chemokine receptors under pathological conditions—may be implicated in HIV-induced neuropathogenesis.