Table 1. Mean and s.d. of Mcm2, Ki67 and geminin LI and median with percentiles in the Mcm2/Ki67 and geminin/Ki67 ratios in NOM, all OEDs and OSCC.
| Labelling index mean (s.d.) | Median (25–75%) | |||||
|---|---|---|---|---|---|---|
| Mcm2 | Ki67 | Geminin | Stat. GLM | Mcm2/Ki67 ratio | Geminin/Ki67 ratio | |
| NOM (n=15) | 39.94 (8.1) | 22.94 (5.2) | 9.95 (2.1) | P<0.001 | 1.75 (1.42–2.11) | 0.43 (0.37–0.56) |
| OED (n=81) | 73.62 (12.1) | 44.55 (11.1) | 24.40 (7.2) | P<0.001 | 1.75 (1.42–1.97)a | 0.54 (0.47–0.62) |
| OSCC (n=38) | 81.16 (4.9) | 59.03 (9.6) | 34.08 (6.3) | P<0.001 | 1.36 (1.23–1.55) | 0.58 (0.51–0.62) |
| ANOVA test | P<0.001 | P<0.001 | P<0.001 | P⧫=0.00 | P⧫=0.01 | |
Abbreviations: All OED=all oral epithelial dysplasias (OED that progressed and did not progress to OSCC); GLM=general linear model; NOM=normal oral mucosa; OSCC=oral squamous-cell carcinomas from progressing OED; P⧫=Kruskal-Wallis test; ANOVA=analysis of variance.
a
Note: The median Mcm2/Ki67 OED has a lower 75 percentile than NOM, therefore it has proportionally fewer high values, meaning it is actually lower hence the Kruskal–Wallis test.