Figure 3.

Cellular growth inhibition by erlotinib of Caco-2 and WiDr HF- and LF-adapted cells and MCF-7/MR cells. Growth inhibition by erlotinib was determined after 72 h of drug exposure in Caco-2 (A) and WiDr (B) HF- and LF-adapted cells and MCF-7/MR (C) cells. The BCRP-specific inhibitor Ko143 was added 15 min before the drug and was present during the next 72 h at a concentration of 200 nM. Shown are the IC₅₀ values, presented as arithmetic means±s.e.m., of at least three independent experiments. ^*P<0.05 versus HF cells. ^#P<0.05 versus LF/FA cells–Ko143.