Table 3. Univariate analysis of biological, socioeconomic, and nutritional variables as predictors for TRM stratified by diagnosis.
|
ALL
|
AML
|
|||||
|---|---|---|---|---|---|---|
| HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
| Biological variables | ||||||
| Age (years) | 0.93 | (0.85, 1.02) | 0.13 | 0.99 | (0.89, 1.11) | 0.90 |
| DNA index | 0.57 | (0.20, 1.63) | 0.29 | |||
| B-precursor immunophenotype | 0.53 | (0.26, 1.09) | 0.08 | |||
| High-risk group | 0.86 | (0.50, 1.49) | 0.60 | |||
| FAB class (M5 vs other) | 1.95 | (0.57, 6.66) | 0.29 | |||
| Initial WBC (per 10 × 109/l) | 1.00 | (1.00, 1.00) | 0.05 | 1.00 | (1.00, 1.00) | 0.31 |
| Initial haemoglobin (g l−1) | 0.98 | (0.91, 1.07) | 0.70 | 1.01 | (0.87, 1.17) | 0.88 |
| Socioeconomic variables | ||||||
| Hours to clinic | 0.97 | (0.84, 1.11) | 0.61 | 1.01 | (0.73, 1.39) | 0.96 |
| Cost to travel to clinic | 1.02 | (0.93, 1.11) | 0.72 | 1.08 | (0.79, 1.50) | 0.62 |
| Income (per $100) | 0.81 | (0.66, 0.99) | 0.04 | 1.04 | (0.89, 1.22) | 0.61 |
| Presence of telephone | 0.75 | (0.41, 1.36) | 0.34 | 1.04 | (0.41, 2.68) | 0.93 |
| Number of family members | 0.94 | (0.80, 1.09) | 0.39 | 0.98 | (0.81, 1.18) | 0.82 |
| Parental education category | 0.46 | (0.23, 0.89) | 0.02 | 0.94 | (0.36, 2.42) | 0.89 |
| Nutritional variables | ||||||
| Body mass index percentile | 1.00 | (0.99, 1.02) | 0.42 | 1.00 | (0.99, 1.02) | 0.87 |
| Triceps skin-fold thickness percentile | 1.00 | (0.98, 1.02) | 0.86 | 1.02 | (0.98, 1.06) | 0.29 |
| Mid-upper arm circumference percentile | 1.01 | (0.99, 1.03) | 0.38 | 1.03 | (1.00, 1.06) | 0.06 |
Abbreviations: ALL=acute lymphoblastic leukaemia; AML=acute myeloid leukaemia; BMI=body mass index; CI=confidence interval; HR=hazard ratio; TRM=treatment-related mortality; WBC=white blood cell count.