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. 2008 Oct 27;587(Pt 1):41–48. doi: 10.1113/jphysiol.2008.163410

Figure 1. Evidence for SGLT-mediated glucosensing in cultured GE neurones.

Figure 1

A, cartoon of the experimental set up; Ψ represents the membrane potential. B, stimulation of activity (calcium signal) of a GE neuron by glucose (G, numbers are concentrations in mm) is blocked by SGLT inhibitor phloridzin (Phl, 100 nm). C, stimulation of a GE neuron by a non-metabolizable sugar, α-MDG, and block of responses to both glucose and α-MDG by removal of extracellular sodium (0 Na+). B and C are from O’Malley et al. (2006). Copyright © 2006 American Diabetes Association. From Diabetes®, Vol. 55, 2006; 3381–3386. Reprinted with permission from The American Diabetes Association.

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