Table 2.

Oxidative stress

	AMS– (n= 9)			AMS+ (n= 9)
GROUP:
CONDITION:	Normoxia	Hypoxia	Δ	Normoxia	Hypoxia	Δ	Main effect
Free radicals
A•− (AU/√G)	1617 ± 285	1822 ± 348*	205 ± 161	1809 ± 412	2271 ± 474*†	461 ± 215†	Condition main effect/Group × Condition interaction
Lipid peroxidation
LOOH (μmol l−1)	0.61 ± 0.09	0.82 ± 0.19	0.21 ± 0.22	0.69 ± 0.15	1.03 ± 0.20	0.34 ± 0.20	Group and Condition main effects
LDL time at ½max (min)	57.2 ± 4.5	54.8 ± 4.1	–2.4 ± 3.6	60.8 ± 8.1	55.1 ± 8.4	–5.7 ± 3.9	Condition main effect
Antioxidants
Ascorbic acid (μmol l−1)	42.1 ± 18.6	40.7 ± 21.1	–1.5 ± 4.9	53.9 ± 21.2	40.5 ± 12.0*	–13.4 ± 12.6†*	Condition main effect Group × Condition interaction
α-Tocopherol (μmol l−1)	22.2 ± 4.5	22.9 ± 4.7	0.7 ± 1.2	24.2 ± 2.8	24.9 ± 2.7	0.7 ± 0.8	Condition main effect
γ-Tocopherol (μmol l−1)	1.9 ± 0.4	1.9 ± 0.4	0.0 ± 0.3	2.5 ± 0.9	1.9 ± 0.8	–0.6 ± 0.6†	Condition main effect Group × Condition interaction
β-carotene (μmol l−1)	0.42 ± 0.27	0.50 ± 0.30	0.09 ± 0.22	0.37 ± 0.27	0.46 ± 0.26	0.09 ± 0.11	Condition main effect
Retinol (μmol l−1)	1.88 ± 0.37	1.77 ± 0.33	–0.11 ± 0.14	1.93 ± 0.24	1.80 ± 0.26	–0.13 ± 0.11	Condition main effect
Lycopene (μmol l−1)	0.47 ± 0.26	0.71 ± 0.48	0.23 ± 0.47	0.53 ± 0.47	0.67 ± 0.41	0.15 ± 0.21	Condition main effect

Values are mean ±s.d.; AMS–, subjects without (AMS–) and with (AMS+) acute mountain sickness; main effect for group indicates a pooled (normoxia + hypoxia) difference (P < 0.05) between AMS–versus AMS+; main effect for condition indicates a pooled (AMS–+ AMS+) difference (P < 0.05) between normoxia versus hypoxia;

^*different within and

^†between groups (P < 0.05); A^•−, ascorbate free radical expressed in arbitrary units (AU) width in Gauss (G); LOOH, lipid hydroperoxides; LDL, low density lipoprotein; Δ, delta value (hypoxia minus normoxia).