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A and B, a 45 min pretreatment of hippocampal slices with the p38-MAPK Inhibitor SB203580 (5 μm), did not inhibit the LFS-induced LTD (n= 5, A) nor the DHPG-induced LTD (n= 5, B), in the CA1 region. C, a 60 min pretreatment with the GSK-3β inhibitor SB415286 (10 μm) did not significantly alter the Epac-LTD (n= 5).
