Table 3.

Plasma creatine kinase (CK) activity and the incidence of necrosis in Control and simvastatin-treated animals

Animal	Treatment	CK (IU l−1)	Necrosisa
1	Control	170	—
2	Control	127	—
3	Control	149	—
4	Control	91	*
5	Control	211	*
6	Control	169	—
7	Day 4, 80 mg	168	—
8	Day 4, 80 mg	340	—
9	Day 4, 80 mg	497	—
10	Day 4, 80 mg	151	—
11	Day 4, 80 mg	504	—
12	Day 4, 80 mg	136	—
13	Day 12, 80 mg	189	—
14	Day 12, 80 mg	194	—
15	Day 12, 80 mg	161	—
16	Day 12, 80 mg	11 756	**
17	Day 12, 80 mg	540	**
18	Day 12, 88 mg	32 140	**
19	Day 12, 88 mg	358	**
20	Day 12, 88 mg	128 010	*
21	Day 12, 88 mg	32 500	**

^aIncidence of necrosis: —, none;

^*minimal (up to 10 single fibres affected);

^**mild (up to 20% of fibres in section affected).