Table 3.
Cardiovascular variables, blood metabolites and arterial to internal jugular venous differences for glucose, lactate and O2 during infusion of saline and different concentrations of noradrenaline (NA)
| Saline | Low NA | Medium NA | High NA | |
|---|---|---|---|---|
| HR (beats min−1) | 57 ± 8 | 52 ± 9 | 51 ± 10* | 49 ± 10* |
| CO (l min−1) | 4.8 ± 1.0 | 4.7 ± 0.7 | 4.8 ± 0.7 | 4.8 ± 0.7 |
| MAP (mmHg) | 89 ± 7 | 99 ± 8* | 108 ± 9*† | 115 ± 11*† |
| Sys BP (mmHg) | 123 ± 8 | 135 ± 12* | 146 ± 15*† | 157 ± 22*† |
| Dia BP (mmHg) | 70 ± 6 | 78 ± 6* | 84 ± 6 | 87 ± 7 |
| MCA Vmean (cm s−1) | 56.9 ± 11.2 | 54.8 ± 11.9* | 55.0 ± 11.0 | 55.0 ± 11.7 |
| Arterial glucose (mm) | 5.8 ± 0.6 | 6.0 ± 0.5 | 6.6 ± 0.7* | 7.1 ± 0.8* |
| Arterial lactate (mm) | 0.81 ± 0.23 | 0.80 ± 0.19 | 0.79 ± 0.13 | 0.82 ± 0.13 |
| Arterial O2 (mm) | 8.19 ± 0.50 | 8.45 ± 0.49* | 8.56 ± 0.46* | 8.65 ± 0.51* |
| a-v diff glucose (mm) | 0.58 ± 0.12 | 0.66 ± 0.07* | 0.67 ± 0.14* | 0.65 ± 0.12 |
| a-v diff lactate (mm) | −0.03 ± 0.05 | 0.00 ± 0.07 | −0.02 ± 0.05 | −0.02 ± 0.05 |
| a-v diff O2 (mm) | 2.77 ± 0.53 | 3.40 ± 1.56 | 3.16 ± 0.61 | 3.12 ± 0.63 |
Heart rate (HR), cardiac output (CO), mean arterial pressure (MAP), systolic pressure (Sys BP), diastolic pressure (Dia BP), middle cerebral artery mean blood flow velocity (MCA Vmean), arterial glucose, lactate and O2 and arterial to internal jugular venous differences (a-v diff) of glucose, lactate and O2 during saline and different doses of noradrenaline infusion. Low NA (0.05 μg kg−1 min−1), medium NA (0.1 μg kg−1 min−1) and high NA (0.15 μg kg−1 min−1).
Different from before infusion (P < 0.05)
different from preceding value (P < 0.05). Values are means ±s.d. (n= 10) except for a-v diff (n= 8).