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. 2008 Dec 1;587(Pt 2):345–361. doi: 10.1113/jphysiol.2008.162743

Figure 4. Agonist sensitivity of VTA DAergic neuronal responses.

Figure 4

Whole-cell current responses to the indicated agonists (ACh, choline, RJR-2403, cytisine and nicotine at the indicated concentrations; left to right; period of drug application denoted by bar; 2 s time and 100 or 200 pA current amplitude calibration bars) for type ID (A), IID (B), or IIID receptor-mediated currents (C). Traces in each row (ID, IID or IIID) were recorded from the same neuron. D, efficacies of the indicated agonists at the concentrations shown in A–C in eliciting peak whole-cell currents (ordinate: normalized to the peak current response in the presence of 1 mm ACh; indicated as a horizontal dashed line) for type ID (filled bars), type IID (open bars) or type IIID (cross-hatched bars) responses averaged (+s.e.m.) from 6 to 8 neurons tested. E, percentages of VTA DAergic neuronal responses from 188 VTA dissociated neurons tested.