Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacological features of nicotinic responses in VTA DAergic neurons – agonists
| Type | n | IAch (pA) | Icholine/IACh | IRJR/IACh | Icytisine(pA) | EC50 | Hill | Major subunits |
|---|---|---|---|---|---|---|---|---|
| ID | 13 | 100 ± 14 | 32 ± 4%* | 78 ± 17% | 0 | RJR-2403: 12 μm | 0.9 | α4β2 |
| IID | 7 | 140 ± 14 | 87 ± 7% | 25 ± 7%** | 0 | Choline: 4.6 mm | 0.9 | α7 |
| IIID | 5 | 592 ± 139 | 7 ± 3%** | 20 ± 6%** | 148 ± 41* | Nicotine: 5.1 μm | 0.7 | β4-containing |
P < 0.05 compared to IACh,
P < 0.01 compared to IACh.
